Sorting of the Alzheimer's Disease Amyloid Precursor Protein Mediated by the AP-4 Complex
نویسندگان
چکیده
منابع مشابه
Sorting of the Alzhermer ́s Disease Amyloid Precursor Protein Mediated by the AP-4 Complex. A new Signal-Adaptor Interaction between Alzheimer's Disease Amyloid Precursor
The paper reports the discovery of an entirely novel interaction between a signal from the cytosolic tail of the amyloid precursor protein (APP) and the μ4 subunit of the adaptor protein-4 (AP-4) complex. The novelty of this interaction lies not only in the properties of the APP signal but also in the nature of the binding site on μ4. Biochemical and X-ray crystallographic analysis reveals that...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2010
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2010.01.015